Its nice to be back…nice to see y’all! There have been a few skirmishes with the usual suspects and a few plagues upon my house…but I find that music, mirth and the company of good folks keeps one going on and going strong. So nice to Mr. Plant doing what he did once again like way back when he did it for us on the first intro….gem of a little album too! And Darlin’ Nicci says it’s ok for a bloke to say…”Emmm that there Robert Plant is one sexy old dude….” But back to the tune…. Love this tune for it’s drone which accompanied me in the tube scope MRI thing today….love to y’all!
by Steve Dent | @stevetdent | July 22, 2014 at 6:28 am
So far, HIV has eluded a cure because it installs its genome into human DNA so insidiously that it’s impossible for our immune system to clear it out. While current treatments are effective, a lifetime of toxic drugs is required to prevent its recurrence. But researchers from Temple University may have figured out a way to permanently excise it using a highly-engineered HIV “editor.” Here’s how it works: the team analyzed a part of our immune system that fights infection and built a “guide RNA” strand consisting of 20 nucleotides (RNA building blocks). Those strands were then injected into cells typically infected with HIV, like T-cells. There, they targeted the end parts of the virus’s gene and snipped out all 9,709 nucleotides that made up its genome. Since the guide RNA strand contained no human DNA sequences, it left the host cell intact — but free from HIV.
Though scientists eliminated the virus from cultured cells, there’s still a lot of hurdles to clear before such therapy is ready for human trials. The virus’s highly mutative nature means that there are numerous variants that the treatment would have to remove. The other challenge is to deliver the treatment to every infected cell, since complete removal of the virus is required to cure AIDS. However, Temple researcher Kamel Khalili said that “we are working on a number of strategies so we can take the construct into preclinical studies… we want to eradicate every single copy of HIV-1 from the patent. That will cure AIDS.”
JAZZ AT NIGHT: Stella by Starlight by Miles Davis - Continuing the thread of the last week’s jazz post, by the middle of ‘58, the Davis sextet was in full swing. John Coltrane was back with Miles after his stint with Thelonious Monk finished up, Bill Evans was on piano, Jimmy Cobb took over on drums, and Cannonball manned the alto sax. It was with this group that Miles would soon upend the jazz world.
Several sessions were recorded during ‘58 resulting in the reissue album ‘58 Miles. This included tracks from a studio session in May as well as tracks from a live performance at the Plaza. Stella by Starlight, a famous jazz standard and ballad by Victor Young for the movie The Uninvited was part of the studio session. It is steamy and languid and just so chill as you would expect given the crew. If you have a chance, I highly recommend getting this album, a gem that runs under the radar of more famous albums, but is absolutely stellar.